Possible Metastatic OM (Ocular Melanoma) Treatments for you to discuss with your physician about which ones are right for you. When you are discussing treatment plans, always check ahead to make sure that the treatment plan you looking to use will not disqualify you for a clinical trial in the future. Having a next step treatment plan is a good way to be ready if your current treatment stops working. Your physician can help you develop a treatment plan with next steps and possible clinical trials that are right for you.
Liver Directed therapy
Ablation – minimally invasive procedure used to destroy liver tumors without removing them surgically
- Radiofrequency ablation (RFA): Uses heat generated by radiofrequency waves to destroy tumor cells.
- Microwave ablation (MWA): Uses microwaves to heat and destroy tumor tissue.
- Cryoablation: Freezes tumor cells with a cold probe.
Histotripsy – a promising new technology for the non-invasive treatment of liver tumors. It offers precise, non-thermal destruction of diseased tissue with minimal side effects. As research continues, histotripsy may have potential applications in other types of cancer as well. Histotripsy is currently FDA-approved for the treatment of liver tumors. It is available at select medical centers specializing in interventional radiology.
Embolization – chemotherapy, radiation, immunotherapy
Regional isolation Perfusion
IHP HIA
IHP can only be done one, HIA PHP are less invasive and may be performed multiple times.
Isolated hepatic infusion (IHP), open surgical procedure involving vascular isolation of the liver with high doses of chemotherapy delivered directly to the liver.
PHP double ballon catheter inserted into the inferior vena cava to isolate the blood supply to the liver and then is filtered extracorporeally. Better tolerated than IHP but reports are lacking efficacy results. Most commonly done with Melphalan know as Hepzato Kit from Delcath.
Hepatic chemoemolization drug eluting beads, gelatin sponge, polyvinyl sponge, resorbable microspheres and polyvinyl alcohol particles. Chemoembolization has been well tolerated.
Hepatic immunoembolization
Immunologic stimulant into the hepatic artery followed by an emboli zing agent – Metastatic OM (Ocular Melanoma) Treatments
Hepatic Radioembolization or hepatic trans-arterial radioemboliztion (TARE) or selective internal RT (SIRT) glass or resin yttrium-90 beads are introduced to the hepatic artery.
There is also resection of the tumor that might be appropriate. This is usually done when there are few tumors and are easily accessible. Not all tumors can be resected. Embolization might be done as well.
Visit www.hepzatokit.com for more information about the HEPZATO KIT and PHP.
HEPZATO KIT® (melphalan for injection/hepatic delivery system)
HEPZATO KIT is a liver-directed treatment option for certain adult patients with uveal melanoma that has spread to the liver and cannot be surgically removed.
HEPZATO KIT delivers a high dose of melphalan directly to the liver using a specialized hepatic delivery system. This approach is designed to target tumors in the liver while limiting systemic exposure.
HEPZATO KIT is available only at certified healthcare settings that are specially trained to administer the treatment and manage associated risks through a Risk Evaluation and Mitigation Strategy (REMS) program.
Patients should speak with their care team to determine whether HEPZATO KIT may be an appropriate treatment option.
Find a Certified Treatment Center
HEPZATO KIT is administered only at certified healthcare settings. Patients and caregivers can use the Healthcare Setting Locator below to find participating centers and discuss referral options with their oncology team.
Find a Certified HEPZATO KIT Treatment Center
Immunotherapy is an option your physician might recommend
KIMMTRAK is a bispecific gp100 peptide-HLA-directed CD3 T cell engager indicated for the treatment of HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma.
Tebentafusp-tebn (KIMMTRAK) is a NCCN Category 1† Preferred Regimen for HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma (mUM).11 The website is: https://kimmtrak.com/
Aniti PD-1 mono therapy
Pembrolizumab
Nivolumab
Nivolumab/ipilimumab
Ipilimumab
Crytotoxic Regimens
Dacarbazine
Temozolomide
Paclitaxel
Albumin-bound Paclitaxel
Carboplatin//paclitaxel
Targeted Therapy
Trametinib
Kimmtrak formally known as Tentafusp (IMCgp100) is Now FDA approved. Contact your physician if you would like more information and to see if you are eligible to receive this treatment. For more information visit KIMMTRAKCONNECT.com
KIMMTRAK CONNECT® offers customized support for patients who have been prescribed KIMMTRAK. A dedicated nurse case manager provides services and support tailored to each patient’s individual needs, such as financial assistance, coordination of care across sites, information about what to expect, and one-on-one encouragement. Patients can learn more about the program and enroll at KIMMTRAKCONNECT.com. KIMMTRAK.com
KIMMTRAK.com is a patient website designed to provide helpful information about the product and resources.
TIL
Dendritic Cell Vaccination
