Can a Biopsy Help Predict Who Responds to TIL Therapy?
Read full article: A phase 2 trial tested TIL therapy in metastatic uveal melanoma Response rates were 37% with reactive TIL vs. 0% without Responses lasted a median of 17.3 months A pre-surgery biopsy score, UMIS, helped predict who responded Researchers are now applying the approach to other "cold" cancers For years, many of us [...]
Why Uveal Melanoma Is Different, and What That Means for Treatment
Read full article: Uveal melanoma's distinct biology has made it resist systemic treatment HLA-A*02:01–negative patients have historically had limited options Past choices: liver-directed therapy, off-label combos, or clinical trials OptimUM-02 tested darovasertib plus crizotinib vs. investigator's choice More emerging options are making treatment sequencing more complex If you've ever been told "uveal melanoma isn't like [...]
A Cure In Sight and UT Southwestern Bring the Ocular Melanoma Community Together at Eye Believe in Dallas
Harbour Lab Tour: Attendees stepped inside UT Southwestern's lab to meet the scientists studying ocular melanoma. HEPZATO Demonstration: Drs. Chandrasekaran and Shannon led a closer look at liver-directed treatment for metastatic disease. Expert Medical Program: Sessions covered surveillance, biomarkers, adjuvant therapy, treatment sequencing, and emerging therapies. Patient & Caregiver Support: Programming addressed mental health, caregiving, insurance, advocacy, and [...]
A Trial That Didn’t Go as Planned Still Taught Us Something Important
Read full article: Jefferson researchers tested defactinib plus avutometinib in 12 MUM patients The drug pairing was selected using "synthetic lethality analysis" Tumors didn't shrink: six stayed stable and six progressed The enzyme ALDH1A3 rose in several patients whose disease progressed The findings are guiding a new combination treatment now under consideration Hi friends, If [...]
UNITE OM Launches Global Coalition to Bring the Ocular Melanoma Community Together
Website: https://uniteom.org/ Media Contact A Cure In Sight Founding Member, UNITE OM Email: melody@acureinsight.org Website: https://uniteom.org/ FOR IMMEDIATE RELEASE UNITE OM Launches Global Coalition to Bring the Ocular Melanoma Community Together International coalition brings nonprofit organizations and patient advocates together to strengthen collaboration, share resources, and advance progress for people affected by ocular and [...]
New Clues on Why TIL Immunotherapy Works for Some Melanoma Patients — But Not All
Read full article: The study: Moffitt researchers analyzed 60 advanced melanoma patients from four clinical trials to understand why TIL immunotherapy helps some patients but not others. Cell quality matters: Infusions with more CD8+ T cells and "stem-like memory" T cells were linked to stronger responses. A surprising marker: LAG-3, typically seen as a signal of T-cell "exhaustion," [...]